Rail passengers and motorists are facing further disruption due to signalling failures on the rail networks and continued wet weather.
A severe flood warning is in place in Helston, Cornwall. where 190 residents have been advised to leave their homes.
Paddington rail services - including connections to Heathrow - are now restored after a fault, but there is still severe disruption in Brighton.
Heavy rain forecast for Saturday is likely to flood roads in many areas.
In total, the Environment Agency has issued more than 90 flood warnings, meaning flooding is expected, and more than 270 flood alerts, meaning flooding is possible, for England and Wales.
In Scotland, 12 flood alerts and 16 flood warnings have been issued by the Scottish Environment Protection Agency (Sepa), with Tayside currently the worst affected area.
The Met Office has issued amber weather warnings for heavy rain in south west England, Yorkshire and Humbershire, Wales, central Scotland and the Grampians for Saturday and into Sunday morning.
People rescuedA rest centre has been opened for residents in Helston forced to leave their homes by the rising waters of the River Cober, Cornwall Council has said, although only about five people are using it.
There are reports of more than 50 properties being flooded in Cornwall, five of which are in Helston.
The Environment Agency said widespread flooding of properties was "imminent" and issued a severe flood warning - its highest level, meaning there is a danger to life - for St Johns Road, St Johns Close, Coronation Park and Loe Pool in the town.
David Owens of Cornwall Council said the level of the river is "still continuing to rise, still continuing to be of concern".
Fire crews in Dorset used an inflatable boat to rescue two motorists stuck in standing water near Christchurch on Friday night.
One man had been stuck in his car for five hours, and a woman and child were also rescued from a car on the West Stafford bypass near Dorchester.
Fire crews have attended about 70 flood-related incidents across Cornwall since 00:00 GMT on Saturday, and surface water on the roads is causing dangerous driving conditions for motorists.
The council confirmed the A39 at Perranarworthal was closed due to flooding, with some minor routes in the county currently impassable.
On the rail network, the Heathrow Express and Heathrow Connect rail services were suspended overnight after signalling problems on the Great Western mainline near Hayes and Harlington.
However, following overnight repair work, a full service to and from London Paddington was restored early on Saturday morning.
Train operators have advised passengers to check the National Rail Enquiries website before travelling.
In other rail developments:
- Flooding is causing disruption near Rhoose Cardiff International Airport
- In the West Country, rail services are suspended between Exeter St Davids and Taunton due to flooding. Replacement buses are in operation but Network Rail are warning journey times could be increased by up to an hour
- A landslip at Glazebrook near Manchester on Friday afternoon has disrupted rail services between Manchester, Liverpool and Warrington. A reduced service is expected to continue until further notice
- A lineside fire has damaged electrical equipment and caused signalling problems at Preston Park near Brighton, with disruption expected to continue until Sunday. Rail services, including services to and from Gatwick airport, are able to run but at a reduced frequency
Elsewhere on the roads, the A38 eastbound near Plymouth is closed due to flooding and in northern England, the wet weather has forced the closure of the A19 in both directions near Stockton-on-Tees.
With motorists taking to the roads before Christmas, Miranda Schunke from breakdown service Green Flag said she was expecting roads in the Midlands and London to be the busiest over the weekend.
"The M4 and M5 corridor where they meet, that will be busy as people try and head down to Devon and Cornwall. Obviously there's flooding potential there as well so you need to be careful.
"As people try and get out of London, the M40, the M4 and M3 are also going to be very busy," she added.
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