A group of Conservative backbench MPs is to publish a report later calling for a substantial return of powers to the UK from the European Union.
Fresh Start, which says it is backed by more than 100 Tory MPs, wants the UK to remain in the union, but with "significant revisions" to treaties.
Foreign Secretary William Hague has backed the report.
Its publication comes ahead of Prime Minister David Cameron's long-awaited speech on the UK and Europe on Friday.
In his address in the Netherlands, Mr Cameron is expected to support a loosening of the UK's relationship with the EU, endorsed by a referendum.
However, Ken Clarke, a veteran pro-European, who attends the cabinet as a minister without portfolio, told the Financial Times that any referendum would be a "gamble" that could lead to the UK leaving the union.
"I think if Britain ever does leave the European Union, it will be difficult to adjust to our loss of a leading role in the political evolution of Europe and our reduced role in the global political world," he said.
'Manifesto for change'End Quote Sir Nigel Sheinwald UK's former Washington ambassadorIf Britain is active and influential in Washington, that makes us more influential in Brussels, Delhi and elsewhere"
BBC political correspondent Chris Mason says the breadth of contributions to the debate on the UK's relationship with the EU is a striking indication of the anticipation surrounding Mr Cameron's speech.
Our correspondent says Fresh Start - founded by George Eustice, Andrea Leadsom and Chris Heaton-Harris - aims to provide a range of ideas for a prime minister attempting to strike a new deal at a time when he says the European Union is changing.
Launching its "manifesto for change", the group will demand the repatriation of key powers in order to retain the UK's "national democratic accountability", according to the Daily Telegraph.
It will insist on "significant revisions" to EU treaties, arguing for the return of control over all social and employment law, including the working time directive, which it will highlight as a burden on the UK.
The MPs will also call for the introduction of an "emergency brake" on financial services regulation, and the long term repatriation of agricultural policy to member states.
However, other Conservatives - including Mr Clarke - have urged Mr Cameron to be cautious.
And Deputy Prime Minister Nick Clegg has warned it would be "unwise" to create "a prolonged period of uncertainty" over Britain's relationship with Europe.
Speaking to the Guardian, Britain's former ambassador in Washington, Sir Nigel Sheinwald, said a move away from Europe, or leaving entirely, would diminish the UK's international clout.
He said recent warnings by the US administration urging Britain against staging a distracting referendum was "a conscious decision by the Obama administration to intervene in the UK debate".
Sir Nigel, who is a member of the think tank Business for New Europe, added: "If Britain is active and influential in Washington, that makes us more influential in Brussels, Delhi and elsewhere.
"I just cannot see any logical basis for thinking a move to the sidelines, or particularly a move out of Europe, would be anything other than diminishing to the UK's capacity, standing, influence, ability to get things done and capacity to build coalitions internationally."
'Change under way'The prime minister has faced pressure to hold a referendum on Europe and has been criticised by some in his own party for not doing more to get powers back from the EU to the UK.
Pro-European Tory peer Lord Heseltine and a series of leaders of large British businesses have said the uncertainty caused by the idea of a future referendum would jeopardise the UK's business prospects.
Mr Cameron's speech is expected to contain plans for a future referendum on the nature of the relationship, although he has said he wants the UK to remain within the EU.
The audience will be made up of business people, EU diplomats and other interested parties, Downing Street has confirmed.
Labour has described Mr Cameron's Europe policy as a "shambles".
But the PM has said the EU is already in the process of change because of the recent eurozone crisis.
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