About 57,000 people are set to take part in the 34th Great North Run.
The 13.1-mile Tyneside half marathon, which started in 1981, will this year will see its millionth finisher.
A special event in anticipation of the millionth runner saw thousands gather on Newcastle's quayside on Thursday night.
Brendan Foster, who founded the run, said he was "immensely proud" it would soon reach that milestone.
The race, which starts in Newcastle, had 12,000 participants in its first year.
'World first'The millionth person to complete the run will be announced as part of a ceremony on the finish line at South Shields.
Celebrity runners expected to take part include former Olympic rowing champion James Cracknell, TV personality and former athlete Iwan Thomas and BBC News presenter Sophie Raworth, among others.
The run could see another landmark this year, as double Olympic champion Mo Farah hopes to become the first Briton to win the men's elite race for 29 years.
Farah, who narrowly missed out to Ethiopia's Kenenisa Bekele last year, would be the first British winner since Steve Kenyon in 1985.
Farah said: "This time I want to win it. The Bupa Great North Run is a big race and it would be nice to have a win in it."
Fellow Briton Andy Vernon, who won a silver and a bronze at the European Championship last month, will also take part, as will Bekele.
The women's field is led by Ethiopian pair Tirunesh Dibaba, the multiple Olympic and world champion, and the 2012 Olympic champion Tiki Gelana.
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