Funding for the NHS in England will be protected from cuts for five years if the Conservatives win next year's general election, David Cameron is to say.
He will promise real terms increases in health spending in his main speech to the Conservative conference.
It is a repeat of the policy on which he fought the 2010 general election.
Mr Cameron will say it is only possible because of the strength of the economy under his party's stewardship.
And he will ask voters for another five years to finish the job of recovery.
BBC political editor Nick Robinson said he had been told to expect "a really significant policy announcement" in Mr Cameron's speech.
'Strong economy'Mr Cameron will hail NHS advances in DNA research - making a passing reference to his profoundly disabled son Ivan, who died in 2009 - telling party members: "The next Conservative government will protect the NHS budget and continue to invest more.
"Because we know this truth - something Labour will never acknowledge and we will never forget - you can only have a strong NHS if you have a strong economy."
NHS spending has risen at just above the rate of inflation since 2010 but critics argue this amounts to a budget freeze because of increased demand for its services and higher pension costs.
The prime minster has also faced criticism from within his own party over the NHS ring-fence as it means a big squeeze on the budgets of other departments.
Mr Cameron will seek to use his final conference speech before the general election to make an emotional appeal to voters and show his party has more to offer them than austerity.
"I love this country - and my goal is this," he will say.
"To make Britain a country that everyone is proud to call home. That doesn't just mean having the fastest-growing economy, or climbing some international league table.
"I didn't come into politics to make the lines in the graphs go in the right direction. I want to help you live a better life."
UKIP defectionsThe party has unveiled a string of policies this week - on health, housing and pensions - that it hopes will show hard-pressed voters it is on their side.
Chancellor George Osborne also unveiled a two-year freeze on working-age benefits, criticised by some as an attack on the poor.
The conference has also been overshadowed to some extent by rumours about possible further defections after MP Mark Reckless's surprise decision to jump ship to UKIP.
On the eve of Mr Cameron's speech, former Conservative Party donor Arron Banks announced he was switching his allegiance to Nigel Farage's party and could stand in next May's election.
The insurance entrepreneur, who has donated more than £250,000 to the Tories since David Cameron became leader in 2005, said Mr Cameron's goal of renegotiating powers back from the EU was a "myth".
House of Commons Leader William Hague hit back, saying he had never heard of Mr Banks.
The prime minister's task is to banish the defections from his party's mind and give them a clear message to sell to voters on the doorstep next May.
"If our economic plan for the past four years has been about our country, and saving it from economic ruin, our plan for the next five years will be about you and your family and helping you get on," he will tell the party faithful.
'Pinch of salt'Aides said Mr Cameron will deliver his speech from behind a lectern with notes - in clear contrast to Labour leader Ed Miliband who last week came in for some flak for forgetting key passages of his speech.
He will also hail the strength of his frontbench team - another area in which the Conservatives feel they have an advantage over Labour.
Shadow health secretary Andy Burnham said Mr Cameron's promises on the NHS "have been shown to be not worth the paper they are written on".
"People will take David Cameron's pre-election pledges on the NHS with a large pinch of salt," he said.
"Last time, he promised 'real-terms increases' but then cut NHS spending in his very first year in office.
"He promised 'no top-down reorganisation' but then brought forward the biggest ever, throwing the NHS into chaos and siphoning £3bn out of front-line care to pay for it.
"He promised no privatisation but has proceeded to put NHS services up for sale without the permission of the public. He promised to protect the NHS but its getting harder to see your GP and waiting times are going up."
Are you affected by the issues raised in this story? If you would be willing to be interviewed about this by the BBC then please email your experiences and a contact phone number to haveyoursay@bbc.co.uk.
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